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XNA Nucleic Acid Lab

Design Life Beyond DNA - Build Synthetic Genetic Polymers!

🎯 The Future of Medicine: XNA Therapeutics
25+ FDA-approved oligonucleotide drugs β€’ Nuclease-resistant β€’ Programmable gene silencing
25+
FDA Approved Drugs
6
XNA Backbone Types
10⁢×
Nuclease Resistance
99%
Polymerase Fidelity

🎯 Choose Your XNA Journey

🌟
Beginner
What is XNA?
βš—οΈ
Intermediate
Build XNA molecules
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Expert
Design XNAzymes

πŸ€” What Are Xenonucleic Acids (XNA)?

Imagine DNA as the original LEGO set - it's amazing, but limited to certain shapes. XNA is like getting a whole new type of LEGO blocks! Scientists replace the sugar backbone (the part that holds everything together) with synthetic alternatives. The result? Genetic molecules that are invisible to natural enzymes and can survive in the body much longer!

Why does this matter? XNA opens doors to revolutionary applications:

πŸ’Š
Cancer Therapy
Target specific mutations like KRAS G12D
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Gene Silencing
Turn off disease-causing genes
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Diagnostics
Detect cancer biomarkers in blood
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Antiviral
Block viral replication
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Synthetic Biology
Create orthogonal genetic systems
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Data Storage
Store data for millennia
🧬 Select XNA Type
πŸ“ Enter Sequence
Use A, T, G, C (or U for RNA)
βš™οΈ Parameters
Helix Twist 36Β°
Helix Rise 3.4Γ…
TNA Ξ±-L-Threofuranosyl Nucleic Acid
Sugar Structure
4-carbon threose
Nuclease Stability
Very High
DNA/RNA Pairing
Yes (Watson-Crick)
Key Applications
Aptamers, Therapeutics

πŸ§ͺ XNAzyme Lab: Target Cancer Mutations

XNAzymes are artificial enzymes made of XNA that can cut specific RNA sequences. The FR6_1 FANAzyme can target cancer mutations with single-nucleotide precision!

KRAS Oncogene
G12D Mutation
Pancreatic, Colorectal Cancer
BRAF Oncogene
V600E Mutation
Melanoma, Thyroid Cancer
miR-21
OncomiR
Multiple Cancers
Target mRNA Sequence:
5'-AUGAACGAUGGUGCU-3'

πŸ“… FDA-Approved Oligonucleotide Therapeutics Timeline

1998
Vitravene (fomivirsen)
First antisense drug - CMV retinitis in AIDS patients
2004
Macugen (pegaptanib)
First aptamer drug - Age-related macular degeneration
2016
Spinraza (nusinersen)
Breakthrough for spinal muscular atrophy
2018
Onpattro (patisiran)
First RNAi drug - hereditary ATTR amyloidosis
2024
Imetelstat (RYTELO)
Telomerase inhibitor for blood cancer
2025
25+ Drugs Approved
Including ASOs, siRNAs, aptamers for rare diseases

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Achievement Unlocked!

You built your first XNA molecule

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Welcome to XNA Lab!

Explore xenonucleic acids - synthetic genetic polymers that transcend natural DNA. Build TNA, HNA, FANA and more. Ready to design the future of medicine?

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